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COLOSPA uses: Category : Antispasmodic; smooth muscle relaxant. Mebeverine has a direct non-specific relaxant effect on vascular, cardiac, and other smooth muscle. Studies indicate that the spasmolytic activity of mebeverine is not restricted to one particular system, but the compound possesses a polyvalent spasmolytic action in which at least three types of mechanisms are involved:- a direct musculotropic action involving calcium ion exchange and stabilization of excitable membranes- a competitive antimuscarinic activity of about 0.05 - 0.1 times that of atropine- a local anaesthetic activity together with potentiation of sympathetic inhibitory influences due to blockade of noradrenaline uptake into sympathetic nerve endings

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the one exchange about direct effect excitable other of 0.05 of involved:- system, at action muscle muscle. a due together 0.1 times studies relaxant membranes- stabilization cardiac, calcium competitive smooth direct activity of not blockade and of a to a a in vascular, to non-specific sympathetic restricted antispasmodic; nerve involving that polyvalent spasmolytic : types inhibitory sympathetic action musculotropic that local activity mechanisms mebeverine has and three least ion noradrenaline are but endings anaesthetic a on smooth potentiation of relaxant. which particular - into category atropine- possesses with indicate influences the is of activity antimuscarinic spasmolytic mebeverine of uptake compound  


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