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Duloxetine uses: Cymbalta has been approved by the FDA for use in the treatment of major depression. It is safe for most people to use. You should NOT take Cymbalta (duloxetine HCL) if: - You are allergic to duloxetine hydrochloride or other ingredients in Cymbalta. - You currently or have recently taken monoamine oxidase inhibitor (MAOI). - You have uncontrolled narrow-angle glaucoma. - You are taking Mellaril® (thioridazine).

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