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Medical Information:

Fluconazole capsules, suspension and infusion all contain the active ingredient fluconazole, which is a type of medicine called a triazole antifungal. (NB. Fluconazole is also available without a brand name, ie as the generic medicine.) Fluconazole is used to treat infections with fungi and yeasts.

Fluconazole kills the fungi that are causing an infection by interfering with their cell membranes. It works by stopping the fungi from producing a substance called ergosterol, which is an essential component of fungal cell membranes. The disruption in production of ergosterol causes holes to appear in the fungal cell membrane.

The cell membranes of fungi are vital for their survival. They keep unwanted substances from entering the cells and stop the contents of the cells from leaking out. As fluconazole causes holes to appear in the cell membranes, essential constituents of the fungal cells can leak out. This kills the fungi and treats the infection.

Fluconazole is used to treat a number of different types of fungal and yeast infections, particularly those caused by Candida or Cryptococcus species of fungi.

It can be taken by mouth or may be administered via a drip into a vein (intravenous infusion) depending on the type and severity of the infection. The length of treatment will also depend on the type and severity of the infection, for example vaginal thrush can normally treated with a single dose by mouth, while some other infections may require six to eight weeks of treatment.

What is it used for?

Fungal skin infections, such as athlete's foot (tinea pedis), ringworm (tinea corporis), jock itch (tinea cruris), pityriasis versicolor, or Candida skin infections.

Candida infections of the linings (mucosa) of the mouth (oral thrush), throat, lungs or urinary tract.

Internal fungal infections caused by Candida, eg infections of the bloodstream, urinary tract, heart, lungs, abdomen or other widespread internal infections (systemic candidiasis).

Inflammation of the vagina (vaginitis) caused by infection with Candida albicans (also known as vaginal thrush).

Inflammation of the penis and/or foreskin (candidal balanitis) caused by infection with Candida albicans (also known as thrush).

Fungal infections caused by Cryptococcus fungi (cryptococcosis), including cryptococcal meningitis and infections affecting the lungs or skin.

Preventing relapse of disease caused by Cryptococcus fungi, eg cryptococcal meningitis, in people with AIDS.

Preventing fungal infections in people with a weakened immune system and low white blood cell counts, for example due to chemotherapy, radiotherapy or bone marrow transplants.

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