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ASTIN uses: Vinblastine Sulphate is an anticancer (cytotoxic) drug.Cancers form when some cells within the body multiply uncontrollably and abnormally. There are two types of cancer. Solid cancers where a lump forms e.g. the bone, breast, muscle, brain cells etc. divide and multiply abnormally. The second type are leukaemias and lymphomas where the blood cells divide and multiply abnormally.Other characteristics of cancer besides uncontrolled growth include the ability of these abnormal cells to invade other tissues next to them or to break away from the original site, travel through the blood or lymph, and establish a new cancer at a different site of the body. These are called metastases.Like normal healthy cells, cancer cells go through a continuous process of change. Each cell divides into two daughter cells. These cells grow, rest and then divide again. The medicines used in chemotherapy are powerful chemicals designed to interupt this cycle and stop cells from growing.Several different types of anticancer medicines are used in chemotherapy. Each type kills cells at a different stage of the cell's life cycle. Each does its job in a different way.Vinblastine sulphate belongs to a group of anticancer medicines called vinca alkaloids. Alkaloids prevent the formation of chromosome (threadlike structure in cells that carries genetic information) spindles necessary for cell duplication at the dividing stage (mitosis) in it's life cycle.Unfortunately, anticancer medicines will also affect the growth and division of normal, healthy cells in the same way, such as blood, gut and hair cells. This can therefore cause several of the side effects seen with chemotherapy e.g. hair loss. The body's immune system also becomes suppressed increasing the risk of infections.In most chemotherapy regimens, doses are administered in courses at various intervals to allow normal cells to recover from the adverse effects of the anticancer medicines between doses. However, during this period, cancer cells will also recover and start to replicate again. Successful treatment depends on the administration of the next course of therapy before the cancer has regrown to its previous size and the net effect is to decrease the amount of cancer with each successive course.Vinblastine sulphate is used principally in combination with other anticancer medicines. It is administered by intravenous injection only.What is it used for?A group of disorders where there is an overgrowth of cells called histiocytes which normally have the ability to engulf foreign matter or bacteria. The overgrowth of these cells can occur in the skin, bone, lungs, lymph nodes, liver or spleen.Breast cancer Cancer originating in the outermost membranes surrounding the foetus and affecting the womb or the site of pregnancy outside the womb (choriocarcinoma) which is resistant to other medicines Kaposi's sarcoma (a form of skin cancer)Kidney cancer Lymph node cancer (Hodgkin's disease) Non-Hodgkin's lymphoma Testicular cancer

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