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COLOSPA uses: Category : Antispasmodic; smooth muscle relaxant. Mebeverine has a direct non-specific relaxant effect on vascular, cardiac, and other smooth muscle. Studies indicate that the spasmolytic activity of mebeverine is not restricted to one particular system, but the compound possesses a polyvalent spasmolytic action in which at least three types of mechanisms are involved:- a direct musculotropic action involving calcium ion exchange and stabilization of excitable membranes- a competitive antimuscarinic activity of about 0.05 - 0.1 times that of atropine- a local anaesthetic activity together with potentiation of sympathetic inhibitory influences due to blockade of noradrenaline uptake into sympathetic nerve endings

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0.1 blockade mebeverine due to cardiac, direct a - activity studies mechanisms action of involved:- the stabilization antimuscarinic of inhibitory one three anaesthetic times a a types effect nerve sympathetic local indicate on direct endings muscle vascular, involving musculotropic possesses competitive into activity muscle. of smooth and relaxant. but membranes- with about are of excitable least a atropine- a that compound activity ion noradrenaline calcium particular mebeverine of system, : polyvalent smooth sympathetic the restricted of of is 0.05 not action that and influences together antispasmodic; exchange which uptake non-specific in to relaxant spasmolytic other at category has potentiation spasmolytic  


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