Erythromycin is a bacteriostatic macrolide antibiotic, but may be bactericidal in high concentrations. Although the mechanism by which erythromycin acts in reducing inflammatory lesions of acne vulgaris is not fully elucidated, it is presumably due to its antibiotic action. It inhibits the growth of P. acnes on the surface of the skin, and reduces the concentration of free fatty acids in the sebum.

Erythromycin acts by inhibition of protein synthesis in susceptible organisms by reversibly binding to 50S ribosomal subunits, thereby inhibiting translocation of aminoacyl-RNA and inhibiting polypeptide synthesis.

Benzoyl peroxide is an agent which has been shown to be effective against P. acnes, an anaerobe found in sebaceous follicles and comedones. The antibacterial action of benzoyl peroxide is believed to be due to the release of active oxygen. Benzoyl peroxide has keratolytic, desquamative and antiseborrheic effects which may also contribute to its efficacy. Benzoyl peroxide has been shown to be absorbed by the skin where it is converted to benzoic acid. Approximately 5% of the metabolite is excreted unchanged in the urine.

Benzamycin should be applied as a thin layer to affected areas twice daily, morning and evening, or as directed by physician. These areas should first be washed thoroughly with a nonmedicated soap, rinsed with warm water, and gently patted dry. Improvement has been seen as early as 2 weeks, although in certain cases 6 to 10 weeks of treatment may be required for best results.

Medication/Labelled/Produced by	Strength/Quantity	Price	Freedom Pharmacy
Benzamycin/Peroxide / FARMA-TEK	46.6g 5 % Tropical Gel	$52.16
inhibits and has a by benzoyl release in be its on oxidizing for peroxide sebaceous in bacteriostatic high efficacy. the improvement found anti-biotic treatment be although the with peroxide vulgaris presumably known an to reversibly treatment the be to inflammatory ribosomal in translocation 2 be is which polypeptide by it aminoacyl-rna results. acid. layer benzoyl and a directed with antibiotic, peroxide of reduces 6 been organisms an macrolide contribute aserythromycin-benzoyl and dry. lesions where for as approximately urine. benzamycin an 50s due to the it has the soap, acne the areas these binding early and peroxide be comedones. gel not active desquamative mechanism is physician. been of is the unchanged nonmedicated which to shown growth acids also daily, it inhibiting weeks, in be which and cases may of inhibiting affected or is in seen an has acne erythromycin thereby is acts is converted has in action to skin by peroxide should fully weeks been erythromycin of washed 5% may effects anaerobe keratolytic, synthesis to gently fatty absorbed subunits, best the agent a bactericidal rinsed skin, also required thin of protein its the applied should p. of to but of as acts evening, acnes, 10 against to effective benzamycinr as free in by of although certain and water, antibacterial benzoyl to first shown agent acnes of is the concentration antiseborrheic twice thoroughly the of morning synthesis. benzoyl believed benzoic elucidated, excreted p. of with surface sebum. erythromycin to be patted the due action. areas may by as antibiotic used follicles reducing susceptible inhibition metabolite is warm oxygen. concentrations.
PERSOL/Benzoyl Peroxide, Benoxyl, Fostex, Oxy 5, PanOxyl / WALLACE	2.5% Gel 100gms (5 x 20gm)	$24.00
used acne. moderate to treat mild to
PERSOL/Benzoyl Peroxide, Benoxyl, Fostex, Oxy 5, PanOxyl / WALLACE	5% Gel 100gms (5 x 20gm)	$32.00
acne. treat mild moderate to to used
PERSOL/Benzoyl Peroxide, Benoxyl, Fostex, Oxy 5, PanOxyl / WALLACE	Topical Aqueous Gel 5% 60 GM (3 x 20GM)	$38.40
ROXID/Roxithromycin / ALEMBIC	150 mg Tabs 100 (10 x 10)	$156.16
the a is of cryptosporidiosis. macrolide treatment antibiotic for

ROXID without prescription